Karen Schneider
Section of Neurology
Department of Pediatrics
karen.schneider@yale.edu

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Research
Intraventricular hemorrhage (IVH), hemorrhage into the germinal matrix tissues of the developing brain, remains a major problem of preterm neonates. My work involves follow-up evaluations of a cohort of infants of 600-1250 grams birth weight who were enrolled between 1989 and 1992 in a prospective, randomized, placebo-controlled multicenter clinical trial to test the hypothesis that low dose indomethacin would lower the incidence and decrease the serverity of IVH.

The in-patient phase of the study has been completed and follow-up evaluations are being conducted at 3 sites on the 440 survivors. The follow-up developmental testing has included mental and motor Bayley scoring at 7 and 18 months corrected age, Stanford-Binet testing at 36 months corrected age, WPPSI-R testing at 54 months and 72 months corrected age, WISC-III testing at 96 months corrected age, and currently WISC-III and language processing testing at 12 years chronologic age. Demographic and neurologic data are also collected. At 96 months corrected age we conducted fMRI and structural MRI testing of the study children and about 30 control children. In the spring of 2002 we will begin MRI testing of the 12-year olds and a group of matched controls.